Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that contribute to nearly all
brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR …

Acute organophosphorus compound (OP) poisoning induces symptoms of the cholinergic
crises with the occurrence of severe epileptic seizures. Seizures are induced by …

Kinetics of NMDA receptor (NMDAR) ion channel opening and closing contribute to their
unique role in synaptic signaling. Agonist binding generates free energy to open a canonical …

AMPA receptors (AMPARs) mediate the majority of excitatory transmission in the brain and
enable the synaptic plasticity that underlies learning. A diverse array of AMPAR signalling …

A wealth of genetic information is available describing single-nucleotide variants in the
human population that appear to be well-tolerated and in and of themselves do not confer …

The aromatic side-chains of phenylalanine, tyrosine, and tryptophan interact with their
environments via both hydrophobic and electrostatic interactions. Determining the extent to …

The short pre-M1 helix within the S1–M1 linker (also referred to as the pre-M1 linker)
between the agonist-binding domain (ABD, S1) and the M1 transmembrane helix of the …