One of the most fascinating questions in regenerative biology is why some animals can
regenerate injured structures while others cannot. Skeletal muscle has a remarkable …

Despite the evolutionary loss of tissue regenerative potential, robust skeletal muscle repair
processes are largely retained even in higher vertebrates. In mammals, the skeletal muscle …

Skeletal muscle regeneration in vertebrates occurs by the activation of quiescent progenitor
cells that express pax7 to repair and replace damaged myofibers. We have developed a …

Skeletal muscles and bones form a joined functional unit sharing a complex mechanical,
biochemical and hormonal crosstalk. A number of factors, including sex hormones …

Accumulation of mutations causing aberrant changes in the genome promotes cancer.
However, mutations do not occur in every cancer subtype, suggesting additional events that …

Skeletal muscles can regenerate after minor injuries, but severe structural damage often
leads to fibrosis in mammals. Whether adult zebrafish possess the capacity to reproduce …

In some rare and striking cases, striated muscle fibers of the skeleton or body wall, which
consist of terminally differentiated syncytia with complex ultrastructures, were found to be …

Electric fish have served as a model system in biology since the 18th century, providing
deep insight into the nature of bioelectrogenesis, the molecular structure of the synapse, and …

The cellular basis for mammalian muscle regeneration has been an area of intense
investigation over recent decades. The consensus is that a specialized self‐renewing stem …

Biology is replete with examples of regeneration, the process that allows animals to replace
or repair cells, tissues and organs. As on land, vertebrates in aquatic environments …