3D Hydrogel Encapsulation Regulates Nephrogenesis in Kidney Organoids
Stem cell‐derived kidney organoids contain nephron segments that recapitulate
morphological and functional aspects of the human kidney. However, directed differentiation …
morphological and functional aspects of the human kidney. However, directed differentiation …
Enhanced associative memory, classification, and learning with active dynamics
Motivated by advances in the field of active matter where nonequilibrium forcing has been
shown to activate new assembly pathways, here we study how nonequilibrium driving in …
shown to activate new assembly pathways, here we study how nonequilibrium driving in …
Robotics-assisted modular assembly of bioactive soft materials for enhanced organ fabrication
Tissue engineering, an interdisciplinary field, aims to restore, maintain, or enhance tissue
function by developing biological substitutes. To establish an optimal microenvironment …
function by developing biological substitutes. To establish an optimal microenvironment …
Memory formation
SR Nagel, S Sastry, Z Zeravcic… - The Journal of Chemical …, 2023 - pubs.aip.org
The recollection of events from our childhood is part of what makes each of us unique. The
storage and manipulation of memories allows us to think and to reason. Repetitive action …
storage and manipulation of memories allows us to think and to reason. Repetitive action …
Observe without disturbing: tracer particles sense local stresses in cell collectives without affecting the cancer cell dynamics
Measurements of local stresses on the cancer cells (CCs), inferred by embedding inert
compressible tracer particles (TPs) in a growing multicellular spheroid (MCS), show that …
compressible tracer particles (TPs) in a growing multicellular spheroid (MCS), show that …
[HTML][HTML] Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis
A recent experiment on zebrafish blastoderm morphogenesis showed that the viscosity (η) of
a non-confluent embryonic tissue grows sharply until a critical cell packing fraction (ϕ S) …
a non-confluent embryonic tissue grows sharply until a critical cell packing fraction (ϕ S) …
Statistical Mechanical theory for spatio-temporal evolution of Intra-tumor heterogeneity in cancers: Analysis of Multiregion sequencing data
Variations in characteristics from one region (sub-population) to another is commonly
observed in complex systems, such as glasses and a collection of cells. Such variations are …
observed in complex systems, such as glasses and a collection of cells. Such variations are …
Enhanced mechanical heterogeneity of cell collectives due to temporal fluctuations in cell elasticity
G Zills, T Datta, AN Malmi-Kakkada - Physical Review E, 2023 - APS
Cells are dynamic systems characterized by temporal variations in biophysical properties
such as stiffness and contractility. Recent studies show that the recruitment and release of …
such as stiffness and contractility. Recent studies show that the recruitment and release of …
Proliferation-driven mechanical feedback regulates cell dynamics in growing tissues
Local stresses in a tissue, a collective property, regulate cell division and apoptosis. In turn,
cell growth and division induce active stresses in the tissue. As a consequence, there is a …
cell growth and division induce active stresses in the tissue. As a consequence, there is a …
Tracer particles sense local stresses in an evolving multicellular spheroid without affecting the anomalous dynamics of the cancer cells
Measurements of local stresses on the cancer cells (CCs), inferred by embedding inert
compressible tracer particles (TPs) in a growing multicellular spheroid (MCS), show that …
compressible tracer particles (TPs) in a growing multicellular spheroid (MCS), show that …