Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …

The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Next-generation genomic sequencing has identified multiple novel molecular alterations in
cancer. Since the identification of DNA methylation and histone modification, it has become …

Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

Summary Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive
Complex 2 (PRC2), which catalyzes histone H3 lysine 27 trimethylation (H3K27me3) at …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

The ubiquitin-proteasome system plays a critical role in biology by regulating protein
degradation. Despite their importance, precise recognition specificity is known for a few of …

Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of
stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase …

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …