RNA drugs and RNA targets for small molecules: principles, progress, and challenges
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
[HTML][HTML] Emerging roles of lncRNA in cancer and therapeutic opportunities
MC Jiang, JJ Ni, WY Cui, BY Wang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Cancer is difficult to cure due to frequent metastasis, and developing effective therapeutic
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …
Therapeutic targeting of long non-coding RNAs in cancer
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
Cas9 as a versatile tool for engineering biology
RNA-guided Cas9 nucleases derived from clustered regularly interspaced short palindromic
repeats (CRISPR)-Cas systems have dramatically transformed our ability to edit the …
repeats (CRISPR)-Cas systems have dramatically transformed our ability to edit the …
Genetic screens in human cells using the CRISPR-Cas9 system
T Wang, JJ Wei, DM Sabatini, ES Lander - Science, 2014 - science.org
The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9
system for genome editing has greatly expanded the toolbox for mammalian genetics …
system for genome editing has greatly expanded the toolbox for mammalian genetics …
Ki67 is a promising molecular target in the diagnosis of cancer
LT Li, G Jiang, Q Chen… - Molecular medicine …, 2015 - spandidos-publications.com
The expression of Ki67 is strongly associated with tumor cell proliferation and growth, and is
widely used in routine pathological investigation as a proliferation marker. The nuclear …
widely used in routine pathological investigation as a proliferation marker. The nuclear …
RNA-guided human genome engineering via Cas9
Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly
interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that …
interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that …
Liposome-based drug co-delivery systems in cancer cells
Combination therapy and nanotechnology offer a promising therapeutic method in cancer
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …
[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry
P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
[HTML][HTML] Molecular mechanisms and biological functions of siRNA
H Dana, GM Chalbatani… - … journal of biomedical …, 2017 - ncbi.nlm.nih.gov
One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …