The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure
JH Campbell, AC Hearps, GE Martin, KC Williams… - Aids, 2014 - journals.lww.com
Monocytes and macrophages play critical roles in HIV transmission, viral spread early in
infection, and as a reservoir of virus throughout infection. There has been a recent …
infection, and as a reservoir of virus throughout infection. There has been a recent …
[HTML][HTML] Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection
CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads
KA Metcalf Pate, CW Pohlmeyer… - The Journal of …, 2015 - academic.oup.com
Background. Sensitive assays are needed for detection of residual human
immunodeficiency virus (HIV) in patients with undetectable plasma viral loads to determine …
immunodeficiency virus (HIV) in patients with undetectable plasma viral loads to determine …
Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4+ T Cells from HIV-Infected Individuals on Suppressive Antiretroviral …
N Madrid-Elena, ML García-Bermejo… - Journal of …, 2018 - Am Soc Microbiol
Maraviroc is a CCR5 antagonist used in the treatment of HIV-1 infection. We and others
have suggested that maraviroc could reactivate latent HIV-1. To test the latency-reversing …
have suggested that maraviroc could reactivate latent HIV-1. To test the latency-reversing …
[HTML][HTML] Effects of combined CCR5/integrase inhibitors-based regimen on mucosal immunity in HIV-infected patients naïve to antiretroviral therapy: a pilot randomized …
S Serrano-Villar, T Sainz, ZM Ma, NS Utay… - PLoS …, 2016 - journals.plos.org
Whether initiation of antiretroviral therapy (ART) regimens aimed at achieving greater
concentrations within gut associated lymphoid tissue (GALT) impacts the level of mucosal …
concentrations within gut associated lymphoid tissue (GALT) impacts the level of mucosal …
[HTML][HTML] Polyanionic carbosilane dendrimers as a new adjuvant in combination with latency reversal agents for HIV treatment
I Relaño-Rodríguez, R Juárez-Sánchez… - Journal of …, 2019 - Springer
Background The major obstacle impeding human immunodeficiency virus-1 (HIV-1)
eradication in antiretroviral treatment (ART) treated HIV-1 subjects is the establishment of …
eradication in antiretroviral treatment (ART) treated HIV-1 subjects is the establishment of …
[HTML][HTML] Prolonged administration of maraviroc reactivates latent HIV in vivo but it does not prevent antiretroviral-free viral rebound
MR López-Huertas, C Gutiérrez, N Madrid-Elena… - Scientific Reports, 2020 - nature.com
Human immunodeficiency virus (HIV) remains incurable due to latent viral reservoirs
established in non-activated CD4 T cells that cannot be eliminated via antiretroviral therapy …
established in non-activated CD4 T cells that cannot be eliminated via antiretroviral therapy …
Total cellular HIV-1 DNA decreases after switching to raltegravir-based regimens in patients with suppressed HIV-1 RNA
B Rossetti, G Meini, C Bianco, S Lamonica… - Journal of Clinical …, 2017 - Elsevier
Background The integrase inhibitor raltegravir has been used to intensify antiretroviral
therapy in patients with undetectable plasma HIV-1RNA, resulting in variable perturbation of …
therapy in patients with undetectable plasma HIV-1RNA, resulting in variable perturbation of …
Nutritional support to reduce mortality in patients with HIV?
In The Lancet HIV, Jane Mallewa and colleagues5 report the results of a large multicentre
clinical trial in HIV clinics in Kenya, Malawi, Uganda, and Zimbabwe in which the …
clinical trial in HIV clinics in Kenya, Malawi, Uganda, and Zimbabwe in which the …
[HTML][HTML] Immunological and pharmacological strategies to reactivate HIV-1 from latently infected cells: a possibility for HIV-1 paediatric patients?
M Martínez-Bonet, MI Clemente, MJ Serramía… - Journal of virus …, 2015 - Elsevier
The limitations to establishing a viral reservoir facilitated by early cART in children could
play a critical role in achieving natural control of viral replication upon discontinuation of …
play a critical role in achieving natural control of viral replication upon discontinuation of …