Alzheimer's disease (AD) is a spatially dynamic pathology that implicates a growing volume
of multiscale data spanning genetic, cellular, tissue, and organ levels of the organization …

Abstract Genome-Wide Association Studies (GWAS) have elucidated the genetic
components of Parkinson's Disease (PD). However, because the vast majority of GWAS …

Objective This study was undertaken to compare the rate of change in cognition between
glucocerebrosidase (GBA) mutation carriers and noncarriers with and without subthalamic …

Personalized medicine promises individualized disease prediction and treatment. The
convergence of machine learning (ML) and available multimodal data is key moving …

Abstract Endocannabinoid (eCB), 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in
the brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of …

Parkinson's disease is one of the most common age-related neurodegenerative disorders.
Although predominantly a motor disorder, cognitive impairment and dementia are important …

Parkinson's disease has a large heritable component and genome-wide association studies
have identified over 90 variants with disease-associated common variants, providing deeper …

Overlapping symptoms and co-pathologies are common in closely related
neurodegenerative diseases (NDDs). Investigating genetic risk variants across these NDDs …

Objective Identification of genetic risk factors for Parkinson disease (PD) has to date been
primarily limited to the study of single nucleotide variants, which only represent a small …

PRKN mutations are the most common recessive cause of Parkinson's disease and are a
promising target for gene and cell replacement therapies. Identification of biallelic PRKN …