Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

Background & Aims Aging is known to exacerbate the progression of alcoholic liver disease
(ALD), but the underlying mechanisms remain obscure. The aim of this study was to use a …

Oxygen is vital for life as it is required for many different enzymatic reactions involved in
intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption …

Mitochondria are dynamic cellular organelles responsible for a large variety of biochemical
processes as energy transduction, REDOX signaling, the biosynthesis of hormones and …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

DNA damage has been implicated in ageing, but direct evidence for a causal relationship is
lacking, owing to the difficulty of inducing defined DNA lesions in cells and tissues without …

Progeroid mouse models display phenotypes in multiple organ systems that suggest
premature aging and resemble features of natural aging of both mice and humans. The …

Aging, the universal phenomenon, affects human health and is the primary risk factor for
major disease pathologies. Progeroid diseases, which mimic aging at an accelerated rate …

The liver is the central metabolic hub for carbohydrate, lipid, and protein metabolism. It is
composed of four major types of cells, including hepatocytes, endothelial cells (ECs), Kupffer …