Aims Right ventricular (RV) dysfunction and pulmonary hypertension (PH) are increasingly
recognized in heart failure with preserved ejection fraction (HFpEF). The prevalence and …

Pulmonary hypertension (PH) is a classic pathophysiological consequence of left-sided
valvular heart disease (VHD). However, as opposed to other forms of PH, there are relatively …

Over the past 2 decades, the syndrome of heart failure with preserved ejection fraction
(HFpEF) received a lot of attention. 1–19 However, little therapeutic progress was made. 20 …

Background Assessment of vascular endothelial function lacks consistency, and
microvascular endothelial function has been only partly assessed in heart failure with …

Mitral regurgitation (MR) is the most common valvular lesion in the United States and the
second-most common valvular lesion requiring surgery in Europe. 1, 2 In the United States …

Mitral valve prolapse (MVP) is a commonly occurring heart condition defined by
enlargement and superior displacement of the mitral valve leaflet (s) during systole …

Aims To assess the association between mitral regurgitation (MR) and left atrial (LA)
structural and functional remodelling and their effect on pulmonary haemodynamics …

Secondary mitral regurgitation (MR) has been extensively studied in heart failure due to
reduced ejection fraction. In contrast, the occurrence and the pathogenesis of secondary MR …

Pulmonary hypertension (PH) secondary to heart failure with preserved ejection fraction
(HFpEF) is an increasingly recognized cause of PH due to an emerging epidemic of HFpEF …

When the TPG and PVR are elevated, Group 2 PH is referred to as reactive (or active) or
mixed, indicating that high mPAP is a combination of elevated PCWP in conjunction with …