Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy.
However, because they also target non-cancerous cells, their administration leads to …

Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …

The binding and release of ligands from their protein targets is central to fundamental
biological processes as well as to drug discovery. Photopharmacology introduces chemical …

In this study, we capitalized on our previously performed crystallographic fragment screen
and developed the antitubulin small molecule Todalam with only two rounds of …

Microtubules and specialized microtubule-containing structures are assembled from
tubulins, an ancient superfamily of essential eukaryotic proteins. Here, we use bioinformatic …

Cytoskeletal proteins are essential for parasite proliferation, growth, and transmission, and
therefore have the potential to serve as drug targets. 1–5 While microtubules and their …

Microtubule-targeting agents (MTAs) have demonstrated remarkable efficacy as antitumor,
antifungal, antiparasitic, and herbicidal agents, finding applications in the clinical, veterinary …

Microtubule-targeting agents (MTAs) bind to one of several distinct sites in the tubulin dimer,
the subunit of microtubules. The binding affinities of MTAs may vary by several orders of …

Cytoskeletal dynamics are essential for cellular homeostasis and development for both
metazoans and protozoans. The function of cytoskeletal elements in protozoans can diverge …

Dinitroaniline derivatives have been widely used as herbicidal agents to control weeds and
grass. Previous studies demonstrated that these compounds also exhibit good antiparasitic …