OBJECTIVES: Randomized clinical trials (RCTs) conducted in adult ICU patients
increasingly include patient-important outcomes other than mortality. This comes with …

PURPOSE American Society of Clinical Oncology recommends that older adults with cancer
being considered for chemotherapy receive geriatric assessment (GA) and management …

Purpose We assessed long-term outcomes in acutely admitted adult patients with delirium
treated in intensive care unit (ICU) with haloperidol versus placebo. Methods We conducted …

Purpose We assessed long-term outcomes of dexamethasone 12 mg versus 6 mg given
daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe …

Background Delirium is common during critical illness and is associated with long-term
cognitive impairment and disability. Antipsychotics are frequently used to treat delirium, but …

Abstract Background Randomised clinical trials (RCTs) conducted in intensive care units
(ICUs) frequently focus on all‐cause mortality, but other patient‐important outcomes are …

Background Trials in critically ill patients increasingly focus on days alive without life support
(DAWOLS) or days alive out of hospital (DAOOH) and health‐related quality of life (HRQoL) …

Introduction Long-term cognitive impairment is one of the most common complications of
critical illness among survivors who receive mechanical ventilation. Recommended oxygen …

There are several methodological challenges when conducting randomised controlled trials
in palliative care. These include worsening function and high mortality, leading to treatment …

Patients who survive critical illness in intensive care are at risk of associated long-term
adverse sequelae that can affect their physical function, cognitive function, and mental …