A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …

Abstract G-quadruplex (G4) binders have been investigated to discover new anticancer
drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the …

Abstract i-Motifs (iMs) are four-stranded DNA structures that form at cytosine (C)-rich
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …

DNA walkers, a type of dynamic nanomachines, have become the subject of burgeoning
research in the field of biology. These walkers are powered by driving forces based on …

EGFR tyrosine kinase inhibitors have made remarkable success in targeted cancer therapy.
However, therapeutic resistance inevitably occurred and EGFR-targeting therapy has been …

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …

KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various
human cancers and implicated in poor survival. The G-quadruplex formed in KRAS …

DNA i-motifs (iMs) are non-canonical C-rich secondary structures implicated in numerous
cellular processes. Though iMs exist throughout the genome, our understanding of iM …

The rapid development of DNA nanotechnology enables the programmable operation of
advanced DNA walkers, mimicking the function of protein motor in living organisms. The …

The importance of non-canonical DNA structures such as G-quadruplexes (G4) and
intercalating-motifs (iMs) in the fine regulation of a variety of cellular processes has been …