Fluoropyrimidines are widely used in the treatment of several types of solid tumors. Although
most often well tolerated, severe toxicity is encountered in~ 20–30% of the patients …

Home to a culturally heterogeneous population, India is also a melting pot of genetic
diversity. The population architecture characterized by multiple endogamous groups with …

Both safety and efficacy of medical treatment can vary depending on the ethnogeographic
background of the patient. One of the reasons underlying this variability is differences in …

Fluoropyrimidines (FP; 5‐fluorouracil, capecitabine, and tegafur) are a commonly prescribed
class of antimetabolite chemotherapies, used for various solid organ malignancies in over 2 …

Pharmacogenomic screening can identify patients with gene variants that predispose them
to the development of severe toxicity from fluoropyrimidine (FP) chemotherapy. Deficiency of …

Fluorouracil, or 5-flourouracil (5-FU), is a chemotherapy agent that belongs to the drug class
of fluoropyrimidines. When given as an intravenous (IV) solution, 5-FU is used in the …

While genomic approaches to precision medicine hold great promise, they remain
prohibitively expensive for developing countries. The precision public health paradigm …

Interethnic variability in drug response arises from genetic differences associated with drug
metabolism, action and transport. These genetic variations can affect drug efficacy as well as …

Background Despite being the second least populated state, Mizoram exhibits the highest
incidence rate of cancer in India. Its inhabitants, constituting an endogamous and isolated …

Colorectal cancer remains one of the most common cancers worldwide and, despite
improvements in treatment options for late-stage metastatic cancer, there are still questions …