Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

The development of simple, efficient, and biocompatible organic luminescent molecules is of
great significance to the clinical transformation of biomaterials. In recent years, purely …

In this Review article, we systematically summarize the design and applications of various
kinds of long-lived emissive probes for bioimaging and biosensing via time-resolved …

Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …

Significance: The nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and
NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular …

Luminescence lifetime imaging has exhibited significant advantages over traditional optical
imaging in terms of precise quantification detection because of the intrinsic stability of …

Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to
secrete adequate levels of insulin. The molecular mechanisms underlying the progressive …

Microglia are highly motile cells that continuously monitor the brain environment and
respond to damage-associated cues. While glucose is the main energy substrate used by …

The brain's energy demands are remarkable both in their intensity and in their moment-to-
moment dynamic range. This perspective considers the evidence for Warburg-like aerobic …