The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

According to present concepts, innate immunity is regulated by receptors that determine
danger levels by responding to molecules that are associated with infection or cellular …

Highlights•NKG2D pathway is significant for both innate and adoptive tumor
immunity.•Soluble and membrane-bound NKG2D ligands confer opposite role in tumor …

Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …

Protein-protein interactions are key components of all signal transduction processes, so
methods to alter these interactions promise to become important tools in dissecting function …

Computationally modeling changes in binding free energies upon mutation (interface ΔΔ G)
allows large-scale prediction and perturbation of protein–protein interactions. Additionally …

The MHC fold is found in proteins that have a range of functions in the maintenance of an
organism's health, from immune regulation to fat metabolism. Well adapted for antigen …

Uveal melanoma (UM) represents the most common intraocular malignancy in adults and
accounts for about 5% of all melanomas. Primary disease can be effectively controlled by …

The recognition of human leukocyte antigen (HLA)-E by the heterodimeric CD94-NKG2
natural killer (NK) receptor family is a central innate mechanism by which NK cells monitor …

The NKG2x/CD94 (x= A, C, E) natural killer-cell receptors perform an important role in
immunosurveillance by binding to HLA-E complexes that exclusively present peptides …