Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding
Dual antiplatelet therapy with aspirin and a P2Y12 receptor blocker is a key strategy to
reduce platelet reactivity and to prevent thrombotic events in patients treated with …
reduce platelet reactivity and to prevent thrombotic events in patients treated with …
Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary …
Aims Although platelet reactivity during P2Y12-inhibitors is associated with stent thrombosis
(ST) and bleeding, standardized and clinically validated thresholds for accurate risk …
(ST) and bleeding, standardized and clinically validated thresholds for accurate risk …
Platelet function monitoring to adjust antiplatelet therapy in elderly patients stented for an acute coronary syndrome (ANTARCTIC): an open-label, blinded-endpoint …
Background Elderly patients are at high risk of ischaemic and bleeding events. Platelet
function monitoring offers the possibility to individualise antiplatelet therapy to improve the …
function monitoring offers the possibility to individualise antiplatelet therapy to improve the …
Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update
Cytochrome P450 (CYP) 2C19 catalyzes the bioactivation of the antiplatelet prodrug
clopidogrel, and CYP2C19 loss‐of‐function alleles impair formation of active metabolites …
clopidogrel, and CYP2C19 loss‐of‐function alleles impair formation of active metabolites …
Clopidogrel pharmacogenetics: state-of-the-art review and the TAILOR-PCI Study
NL Pereira, CS Rihal, DYF So… - Circulation …, 2019 - Am Heart Assoc
Common genetic variation in CYP2C19 (cytochrome P450, family 2, subfamily C,
polypeptide 19)* 2 and* 3 alleles leads to a loss of functional protein, and carriers of these …
polypeptide 19)* 2 and* 3 alleles leads to a loss of functional protein, and carriers of these …
CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis
Context The US Food and Drug Administration recently recommended that CYP2C19
genotyping be considered prior to prescribing clopidogrel, but the American Heart …
genotyping be considered prior to prescribing clopidogrel, but the American Heart …
Expert position paper on the role of platelet function testing in patients undergoing percutaneous coronary intervention
D Aradi, RF Storey, A Komócsi, D Trenk… - European heart …, 2014 - academic.oup.com
Optimizing outcomes after percutaneous coronary intervention (PCI) requires balancing
between the risks of thrombotic and bleeding events in individual patients. 1–3 However …
between the risks of thrombotic and bleeding events in individual patients. 1–3 However …
Current concepts and novel targets for antiplatelet therapy
M Gawaz, T Geisler, O Borst - Nature Reviews Cardiology, 2023 - nature.com
Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …
Platelet aggregometry testing: molecular mechanisms, techniques and clinical implications
K Koltai, G Kesmarky, G Feher, A Tibold… - International journal of …, 2017 - mdpi.com
Platelets play a fundamental role in normal hemostasis, while their inherited or acquired
dysfunctions are involved in a variety of bleeding disorders or thrombotic events. Several …
dysfunctions are involved in a variety of bleeding disorders or thrombotic events. Several …
Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease
Multiple guidelines and consensus papers have addressed the role of antithrombotic
strategies in patients with established coronary artery disease (CAD). Since evidence and …
strategies in patients with established coronary artery disease (CAD). Since evidence and …