Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

ME Carey, ZA Dyson, DJ Ingle, A Amir, MK Aworh… - Elife, 2023 - elifesciences.org
Background: The Global Typhoid Genomics Consortium was established to bring together
the typhoid research community to aggregate and analyse Salmonella enterica serovar …

Assessing the global risk of typhoid outbreaks caused by extensively drug resistant Salmonella Typhi

J Walker, C Chaguza, ND Grubaugh, M Carey… - Nature …, 2023 - nature.com
Since its emergence in 2016, extensively drug resistant (XDR) Salmonella enterica serovar
Typhi (S. Typhi) has become the dominant cause of typhoid fever in Pakistan. The …

Shifting targets: typhoid's transformation from an environmental to a vaccine-preventable disease, 1940–2019

E Webster, PP Lopez, C Kirchhelle - The Lancet Infectious Diseases, 2024 - thelancet.com
Summary 160 years after the discovery of its waterborne transmission and 120 years after
the development of the first-generation of vaccines, typhoid fever remains a major health …

Global diversity and antimicrobial resistance of typhoid fever pathogens: insights from 13,000 Salmonella Typhi genomes

ME Carey, ZA Dyson, DJ Ingle, A Amir, MK Aworh… - medRxiv, 2022 - medrxiv.org
Abstract The Global Typhoid Genomics Consortium was established to bring together the
typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi …

Population structure and antimicrobial resistance patterns of Salmonella Typhi and Paratyphi A amid a phased municipal vaccination campaign in Navi Mumbai, India

KE Da Silva, K Date, N Hirani, C LeBoa, N Jayaprasad… - Mbio, 2023 - Am Soc Microbiol
We performed whole-genome sequencing of 174 Salmonella Typhi and 54 Salmonella
Paratyphi A isolates collected through prospective surveillance in the context of a phased …

Exploring SNP Filtering Strategies: The Influence of Strict vs Soft Core

ML Taouk, LA Featherstone, G Taiaroa, T Seemann… - bioRxiv, 2024 - biorxiv.org
Phylogenetic analyses are crucial for understanding microbial evolution and infectious
disease transmission. Bacterial phylogenies are often inferred from single nucleotide …

RpoS activates formation of Salmonella Typhi biofilms and drives persistence in the gall bladder

SK Desai, Y Zhou, R Dilawari, AL Routh, V Popov… - bioRxiv, 2023 - biorxiv.org
The development of strategies for targeting the asymptomatic carriage of Salmonella Typhi
in chronic typhoid patients has suffered owing to our basic lack of understanding of the …

An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids

A Zuza, A Wailan, C Anscombe, NA Feasey, E Heinz - bioRxiv, 2024 - biorxiv.org
Typhoid fever is a significant public health problem endemic in Southeast Asia and Sub-
Saharan Africa. Antimicrobial treatment of typhoid is however threatened by the increasing …

Recent emergence of cephalosporin resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding blaCTX-M-15 gene

T Priya T, JJ Jacob, V Aravind, T Monisha Priya… - bioRxiv, 2023 - biorxiv.org
The emergence and spread of Salmonella Typhi resistant to third generation cephalosporins
are a serious global health concern. In this study, we have genomically characterized twelve …