ABSTRACT The 37/67‐kDa laminin receptor (LAMR/RPSA) was originally identified as a 67‐
kDa binding protein for laminin, an extracellular matrix glycoprotein that provides cellular …

The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment
is increasingly recognized as a critical factor in cancer progression and the efficacy of …

Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large
variety of tumors and also in tumor associated endothelial cells but mostly absent in …

Background Although therapeutic cancer vaccines have been mostly disappointing in the
clinic, the advent of novel immunotherapies and the future promise of neoantigen-based …

Introduction: The ubiquitously expressed 37 kDa/67 kDa high-affinity laminin receptor
(laminin receptor precursor/laminin receptor, LRP/LR) is a protein found to play several roles …

Background The chemokine MIP-3α (CCL20) binds to CCR6 on immature dendritic cells.
DNA vaccines fusing MIP-3α to melanoma-associated antigens have shown improved …

We are witnessing a new era of immune-mediated cancer therapies and vaccine
development. As the field of cancer vaccines advances into clinical trials, overcoming low …

Fusing antigens to chemokines to target antigen presenting cells (APC) is a promising
method for enhancing immunogenicity of DNA vaccines. However, it is unclear how different …

Beta-defensins, small antimicrobial peptides, are involved in host immune responses to
tumors. In this study, we used beta-defensin 2 (BD2) to explore the possible role of beta …

Cancer/Testis (CT) antigens are considered promising target molecules for immunotherapy.
To identify potential CT antigens, we performed immunoscreening of a testis cDNA library …