[HTML][HTML] B-cell epitope mapping for the design of vaccines and effective diagnostics

TA Ahmad, AE Eweida, SA Sheweita - Trials in Vaccinology, 2016 - Elsevier
The increasing resistance of many microbial strains to antibiotics, delayed laboratory results,
and side effects of many chemotherapeutics has raised the need to search for sensitive …

Life cycle and morphogenesis of the hepatitis E virus

K Himmelsbach, D Bender, E Hildt - Emerging microbes & …, 2018 - Taylor & Francis
Hepatitis E virus (HEV) is transmitted primarily via contaminated water and food by the fecal
oral route and causes epidemics in developing countries. In industrialized countries …

Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection

X Yin, D Ying, S Lhomme, Z Tang… - Proceedings of the …, 2018 - National Acad Sciences
The enterically transmitted hepatitis E virus (HEV) adopts a unique strategy to exit cells by
cloaking its capsid (encoded by the viral ORF2 gene) and circulating in the blood as “quasi …

Urine is a viral antigen reservoir in hepatitis E virus infection

D Ying, Q He, W Tian, Y Chen, X Zhang, S Wang… - Hepatology, 2023 - journals.lww.com
Urine is a viral antigen reservoir in hepatitis E virus infe... : Hepatology Urine is a viral antigen
reservoir in hepatitis E virus infection : Hepatology AASLD Publications Hepatology Liver …

Multimodal investigation of rat hepatitis E virus antigenicity: Implications for infection, diagnostics, and vaccine efficacy

S Sridhar, J Situ, JP Cai, CCY Yip, S Wu, AJX Zhang… - Journal of …, 2021 - Elsevier
Background & Aims Rat hepatitis E virus (Orthohepevirus species C; HEV-C1) is an
emerging cause of viral hepatitis in humans. HEV-C1 is divergent from other HEV variants …

[HTML][HTML] Role of envelopment in the HEV life cycle

X Yin, X Li, Z Feng - Viruses, 2016 - mdpi.com
Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-
enveloped for decades. However, recent studies have revealed that the virus circulating in …

The pressing need for a global HEV vaccine

JM Peron, H Larrue, J Izopet, M Buti - Journal of Hepatology, 2023 - Elsevier
Based on the worldwide distribution of hepatitis E virus (HEV) and its ability to cause major
epidemics in low-income countries, the global availability of a HEV vaccine is a pressing …

[HTML][HTML] Advances in hepatitis E virus biology and pathogenesis

S Lin, YJ Zhang - Viruses, 2021 - mdpi.com
Hepatitis E virus (HEV) is one of the causative agents for liver inflammation across the world.
HEV is a positive-sense single-stranded RNA virus. Human HEV strains mainly belong to …

[HTML][HTML] Structural aspects of hepatitis E virus

F Cancela, O Noceti, J Arbiza, S Mirazo - Archives of Virology, 2022 - Springer
Hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Hepatitis E is an
enterically transmitted zoonotic disease that causes large waterborne epidemic outbreaks in …

[HTML][HTML] An in silico deep learning approach to multi-epitope vaccine design: A hepatitis e virus case study

A Ikram, B Alzahrani, T Zaheer, S Sattar, S Rasheed… - Vaccines, 2023 - mdpi.com
Hepatitis E Virus (HEV) is a major cause of acute and chronic hepatitis. The severity of HEV
infection increases manyfold in pregnant women and immunocompromised patients …