[HTML][HTML] Germinal-center organization and cellular dynamics
CDC Allen, T Okada, JG Cyster - Immunity, 2007 - cell.com
Germinal centers (GCs) are important sites of antibody affinity maturation. In the classical
model, the GC dark zone contains large centroblasts that are rapidly proliferating and …
model, the GC dark zone contains large centroblasts that are rapidly proliferating and …
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases
D Bhattacharya - Immunity, 2022 - cell.com
Many aspects of SARS-CoV-2 have fully conformed with the principles established by
decades of viral immunology research, ultimately leading to the crowning achievement of …
decades of viral immunology research, ultimately leading to the crowning achievement of …
[HTML][HTML] Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens
How precursor frequencies and antigen affinities impact interclonal B cell competition is a
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response
MJ Robinson, MR Dowling, C Pitt, K O'Donnell… - Science …, 2022 - science.org
Vaccines work largely by generating long-lived plasma cells (LLPCs), but knowledge of how
such cells are recruited is sparse. Although it is clear that LLPCs preferentially originate in …
such cells are recruited is sparse. Although it is clear that LLPCs preferentially originate in …
Regulated selection of germinal-center cells into the memory B cell compartment
R Shinnakasu, T Inoue, K Kometani, S Moriyama… - Nature …, 2016 - nature.com
Despite the importance of memory B cells in protection from reinfection, how such memory
cells are selected and generated during germinal-center (GC) reactions remains unclear …
cells are selected and generated during germinal-center (GC) reactions remains unclear …
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation
D Chen, Y Wang, GK Manakkat Vijay, S Fu… - Nature …, 2021 - nature.com
Antigen-activated B cells diversify variable regions of B cell antigen receptors by somatic
hypermutation in germinal centers (GCs). The positive selection of GC B cells that acquire …
hypermutation in germinal centers (GCs). The positive selection of GC B cells that acquire …
[HTML][HTML] Protein amounts of the MYC transcription factor determine germinal center B cell division capacity
High-affinity B cell selection in the germinal center (GC) is governed by signals delivered by
follicular helper T (Tfh) cells to B cells. Selected B cells undergo clonal expansion and …
follicular helper T (Tfh) cells to B cells. Selected B cells undergo clonal expansion and …
[HTML][HTML] MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase
G Teng, P Hakimpour, P Landgraf, A Rice, T Tuschl… - Immunity, 2008 - cell.com
B lymphocytes perform somatic hypermutation and class-switch recombination (CSR) of the
immunoglobulin locus to generate an antibody repertoire diverse in both affinity and …
immunoglobulin locus to generate an antibody repertoire diverse in both affinity and …
Computer-aided antibody design
D Kuroda, H Shirai, MP Jacobson… - … engineering, design & …, 2012 - academic.oup.com
Recent clinical trials using antibodies with low toxicity and high efficiency have raised
expectations for the development of next-generation protein therapeutics. However, the …
expectations for the development of next-generation protein therapeutics. However, the …
[HTML][HTML] Sequential class switching is required for the generation of high affinity IgE antibodies
IgE antibodies with high affinity for their antigens can be stably cross-linked at low
concentrations by trace amounts of antigen, whereas IgE antibodies with low affinity bind …
concentrations by trace amounts of antigen, whereas IgE antibodies with low affinity bind …