In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …

Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …

Dopamine controls various physiological functions in the brain and periphery by acting on its
receptors D1, D2, D3, D4, and D5. Dopamine receptors are G protein–coupled receptors …

The adult brain is a plastic place. To ensure that the mature nervous system's control of
behaviour is flexible in the face of a varying environment, morphological and physiological …

Major depressive disorder (MDD) is characterized by structural and neurochemical changes
in limbic structures, including the hippocampus, that regulate mood and cognitive functions …

Accumulating evidence implicates hippocampal neurogenesis in the pathophysiology of
depression. Psychosocial stress reduces neurogenesis in rodents, whereas chronic …

In all vertebrate species studied thus far, the adult central nervous system harbors neural
stem cells that sustain constitutive neurogenesis, as well as latent neural progenitors that …

We demonstrate a heteromeric D1–D2 dopamine receptor signaling complex in brain that is
coupled to Gq/11 and requires agonist binding to both receptors for G protein activation and …

Although many features of neurogenesis during development and in the adult are intrinsic to
the neurogenic cells themselves, the role of the microenvironment is irrefutable. The …

New neurons and glial cells are generated in an extensive germinal niche adjacent to the
walls of the lateral ventricles in the adult brain. The primary progenitors (B1 cells) have …