Human skin and hair color are visible traits that can vary dramatically within and across
ethnic populations. The genetic makeup of these traits—including polymorphisms in the …

In recent years, melanoma research has undergone a renaissance. What was once viewed,
at least in the metastatic setting, as an intractable and untreatable disease is now revealing …

The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the
regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R …

Dysregulation of the activity of the mechanistic target of rapamycin complex 1 (mTORC1) is
commonly linked to aging, cancer, and genetic disorders such as tuberous sclerosis (TS), a …

Skin cancers are among the most common cancers worldwide and are increasingly
prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of …

Ultraviolet (UV) light is absorbed by nucleic acids, proteins or other endogenous
chromophores, such as porphyrins, flavins and melanin, triggering biological processes in …

Freckles, the lay term for ephelides and lentigines, are important pigmentation
characteristics observed in humans. Both are affected by sunlight; ephelides are largely …

The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic
transmembrane receptor involved in pigmentation, adaptive tanning, and melanoma …

The melanocortin 1 receptor (MC1R), a G s protein–coupled receptor, has an important role
in human pigmentation. We investigated the regulation of expression and activity of the …

The conventional chemotherapeutic treatment of malignant melanoma still remains poorly
efficient in most cases. Thus the use of specific features of these tumors for development of …