Enzyme co-immobilization: Always the biocatalyst designers' choice… or not?

S Arana-Peña, D Carballares… - Biotechnology …, 2021 - Elsevier
The increasing relevance of cascade reactions in biocatalysis has sparked a great interest
for enzyme co-immobilization. Enzyme co-immobilization allows access to some kinetic …

Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Hierarchically encapsulating enzymes with multi-shelled metal-organic frameworks for tandem biocatalytic reactions

T Man, C Xu, XY Liu, D Li, CK Tsung, H Pei… - Nature …, 2022 - nature.com
Biocatalytic transformations in living organisms, such as multi-enzyme catalytic cascades,
proceed in different cellular membrane-compartmentalized organelles with high efficiency …

Multienzymatic cascade reactions via enzyme complex by immobilization

ET Hwang, S Lee - ACS Catalysis, 2019 - ACS Publications
Multienzymatic cascade reactions are a most important technology to succeed in industrial
process development, such as synthesis of pharmaceutical, cosmetic, and nutritional …

Substrate channelling as an approach to cascade reactions

I Wheeldon, SD Minteer, S Banta, SC Barton… - Nature …, 2016 - nature.com
Millions of years of evolution have produced biological systems capable of efficient one-pot
multi-step catalysis. The underlying mechanisms that facilitate these reaction processes are …

Biocatalytic cascades operating on macromolecular scaffolds and in confined environments

M Vázquez-González, C Wang, I Willner - Nature Catalysis, 2020 - nature.com
Biocatalytic cascades guide complex, efficient and selective intracellular transformations.
These unique features originate from the spatial organization of the biocatalysts in confined …

Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades

JC Breger, JN Vranish, E Oh, MH Stewart… - Nature …, 2023 - nature.com
Access to efficient enzymatic channeling is desired for improving all manner of designer
biocatalysis. We demonstrate that enzymes constituting a multistep cascade can self …

Cascade catalysis–strategies and challenges en route to preparative synthetic biology

J Muschiol, C Peters, N Oberleitner… - Chemical …, 2015 - pubs.rsc.org
Nature's smartness and efficient assembling cascade type reactions inspired biologists and
chemists all around the world. Tremendous effort has been directed towards the …

Single-atom platinum nanocatalyst-improved catalytic efficiency with enzyme-DNA supermolecular architectures

R Zeng, W Wang, G Cai, Z Huang, J Tao, D Tang… - Nano Energy, 2020 - Elsevier
Abstract Single-atom catalysts (SACs), a newcomer in the field of nanocatalysis, have
sparked tremendous interest thanks to their high atomic utilization, unsaturated coordination …

Artificial Multienzyme Scaffolds: Pursuing in Vitro Substrate Channeling with an Overview of Current Progress

GA Ellis, WP Klein, G Lasarte-Aragones, M Thakur… - ACS …, 2019 - ACS Publications
Artificial multienzyme scaffolds are being developed for in vitro cascaded biocatalytic activity
and, in particular, accessing substrate channeling. This review covers progress in this field …