Type 2 diabetes mellitus and cardiovascular disease: genetic and epigenetic links

S De Rosa, B Arcidiacono, E Chiefari… - Frontiers in …, 2018 - frontiersin.org
Type 2 diabetes mellitus (DM) is a common metabolic disorder predisposing to diabetic
cardiomyopathy and atherosclerotic cardiovascular disease (CVD), which could lead to …

MicroRNA biomarkers and platelet reactivity: the clot thickens

N Sunderland, P Skroblin, T Barwari… - Circulation …, 2017 - Am Heart Assoc
Over the last few years, several groups have evaluated the potential of microRNAs
(miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss the …

Revisiting platelets and toll-like receptors (TLRs): at the interface of vascular immunity and thrombosis

K Hally, S Fauteux-Daniel… - International journal of …, 2020 - mdpi.com
While platelet function has traditionally been described in the context of maintaining
vascular integrity, recent evidence suggests that platelets can modulate inflammation in a …

MicroRNAs in platelet function and cardiovascular disease

DD McManus, JE Freedman - Nature Reviews Cardiology, 2015 - nature.com
Cardiovascular disease—a leading cause of morbidity and mortality among adults—is
strongly influenced by platelet function through acute thrombotic and atherogenic …

Coronary artery-bypass-graft surgery increases the plasma concentration of exosomes carrying a cargo of cardiac microRNAs: an example of exosome trafficking out …

C Emanueli, AIU Shearn, A Laftah, F Fiorentino… - PLoS one, 2016 - journals.plos.org
Introduction Exosome nanoparticles carry a composite cargo, including microRNAs (miRs).
Cultured cardiovascular cells release miR-containing exosomes. The exosomal trafficking of …

The potential role of platelet-related microRNAs in the development of cardiovascular events in high-risk populations, including diabetic patients: a review

J Pordzik, K Pisarz, S De Rosa, AD Jones… - Frontiers in …, 2018 - frontiersin.org
Platelet activation plays a pivotal role in the development and progression of
atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the …

Clinical application of serum microRNAs in atherosclerotic coronary artery disease

A Kabłak-Ziembicka, R Badacz… - Journal of Clinical …, 2022 - mdpi.com
MicroRNAs (miRs) are promising diagnostic, prognostic and therapeutic biomolecules for
atherosclerotic cardiovascular disease. Atherosclerotic occlusive disease concerns a large …

MiR-223-3p in cardiovascular diseases: a biomarker and potential therapeutic target

MW Zhang, YJ Shen, J Shi, JG Yu - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Cardiovascular diseases, involving vasculopathy, cardiac dysfunction, or circulatory
disturbance, have become the major cause of death globally and brought heavy social …

[HTML][HTML] Circulating ectosomes: Determination of angiogenic microRNAs in type 2 diabetes

E Stępień, M Durak-Kozica, A Kamińska… - Theranostics, 2018 - ncbi.nlm.nih.gov
Ectosomes (Ects) are a subpopulation of extracellular vesicles formed by the process of
plasma membrane shedding. In the present study, we profiled ectosome-specific microRNAs …

Mechanistic role of microRNAs in coupling lipid metabolism and atherosclerosis

J Novák, V Olejníčková, N Tkáčová… - microRNA: Basic Science …, 2015 - Springer
MicroRNAs (miRNAs, miRs) represent a group of powerful and versatile posttranscriptional
regulators of gene expression being involved in the fine control of a plethora of physiological …