The incidence of infections caused by bacteria that are resistant to antibiotics is constantly
increasing. In Europe alone, it has been estimated that each year about 33′ 000 deaths are …

Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR)
Gram-negative infections currently represents an unmet clinical need. Areas covered This …

Importance Current evidence is conflicting for associations of extended-infusion β-lactam (EI-
BL) therapy with clinical outcomes. Objective To investigate the association of EI-BL therapy …

Background Carbapenems are recommended treatment for serious infections caused by
AmpC-producing gram-negative bacteria but can select for carbapenem resistance …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …

The spread of multidrug-resistant bacteria is an ever-growing concern, particularly among
Gram-negative bacteria because of their intrinsic resistance and how quickly they acquire …

Background The optimization of the use of β-lactam antibiotics (BLA) via prolonged infusions
in life-threatening complications such as febrile neutropenia (FN) is still controversial. This …

Background Acute kidney injury is a major complication of vancomycin treatment, especially
when it is co-administered with other nephrotoxins. Objectives This meta-analysis aims to …

Variants of SARS-CoV-2 have emerged that are more transmissible than the original virus or
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …

Antibiotic resistance is a major health problem and will be probably one of the leading
causes of deaths in the coming years. One of the most effective ways to fight against …