Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …

Insulin-like growth factor–I (IGF-I) is a mitogen for prostate epithelial cells. To investigate
associations between plasma IGF levels and prostate cancer risk, a nested case-control …

The insulin-like growth factor 1 (IGF1) signalling pathway has important roles in regulating
cellular proliferation and apoptosis. Converging results from epidemiological research and …

Prostate-specific antigen (PSA) is an androgen-regulated serine protease produced by both
prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum …

Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily* | Endocrine Reviews | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search Menu …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation
and Functions* | Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement …