Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract
Effective evaluation and prediction of aerosol transport deposition in the human respiratory
tracts are critical to aerosol drug delivery and evaluation of inhalation products …
tracts are critical to aerosol drug delivery and evaluation of inhalation products …
[HTML][HTML] Nasal anatomy and sniffing in respiration and olfaction of wild and domestic animals
Animals have been widely utilized as surrogate models for humans in exposure testing,
infectious disease experiments, and immunology studies. However, respiratory diseases …
infectious disease experiments, and immunology studies. However, respiratory diseases …
[HTML][HTML] Effects of mask-wearing on the inhalability and deposition of airborne SARS-CoV-2 aerosols in human upper airway
Even though face masks are well accepted as tools useful in reducing COVID-19
transmissions, their effectiveness in reducing viral loads in the respiratory tract is unclear …
transmissions, their effectiveness in reducing viral loads in the respiratory tract is unclear …
[HTML][HTML] Prediction of airway deformation effect on pulmonary air-particle dynamics: A numerical study
Most existing whole lung models neglect the airway deformation kinematics and assume the
lung airways are static. However, neglecting the airway deformation effect on pulmonary air …
lung airways are static. However, neglecting the airway deformation effect on pulmonary air …
An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition
An understanding of human inter-subject variability is crucial for the implementation of
personalized pulmonary drug delivery as well as exposure assessment of airborne …
personalized pulmonary drug delivery as well as exposure assessment of airborne …
[HTML][HTML] Particle deposition in human lung airways: effects of airflow, particle size, and mechanisms
Characterizing particle deposition in the airways of the human lungs is essential to evaluate
the health effects of particulate air pollution. However, lung deposition is rather complicated …
the health effects of particulate air pollution. However, lung deposition is rather complicated …
[HTML][HTML] SARS COV-2 virus-laden droplets coughed from deep lungs: Numerical quantification in a single-path whole respiratory tract geometry
When an infected person coughs, many virus-laden droplets will be exhaled out of the
mouth. Droplets from deep lungs are especially infectious because the alveoli are the major …
mouth. Droplets from deep lungs are especially infectious because the alveoli are the major …
In Vitro and In Silico Investigations on Drug Delivery in the Mouth-Throat Models with Handihaler®
This work aimed to evaluate the relative inhalation parameters that affect the deposition of
inhaled aerosols, including mouth-throat morphology, airflow rate, and initial condition of …
inhaled aerosols, including mouth-throat morphology, airflow rate, and initial condition of …
Numerical simulation of welding fume lung dosimetry
Exposures to airborne particles and toxic gases generated by welding fabrication activities
will potentially lead to various diseases. Accurate information on the transport and …
will potentially lead to various diseases. Accurate information on the transport and …
[HTML][HTML] Effect of MDI actuation timing on inhalation dosimetry in a human respiratory tract model
Accurate knowledge of the delivery of locally acting drug products, such as metered-dose
inhaler (MDI) formulations, to large and small airways is essential to develop reliable in …
inhaler (MDI) formulations, to large and small airways is essential to develop reliable in …