The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

Although the composition of the human microbiome is now well-studied, the microbiota's> 8
million genes and their regulation remain largely uncharacterized. This knowledge gap is in …

▪ Abstract In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …

The core particle (CP) of the yeast proteasome is composed of four heptameric rings of
subunits arranged in a hollow, barrel-like structure. We report that the CP is autoinhibited by …

Streptococcus pneumoniae is among the most significant causes of bacterial disease in
humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive …

The production of nitric oxide and other reactive nitrogen intermediates (RNI) by
macrophages helps to control infection by Mycobacterium tuberculosis (Mtb). However, the …

Ubiquitin-dependent proteolysis is catalyzed by the 26S proteasome, a dynamic complex of
32 different proteins whose mode of assembly and mechanism of action are poorly …

Machado-Joseph disease is caused by an expansion of a trinucleotide CAG repeat in the
gene encoding the protein ataxin-3. We investigated if ataxin-3 was a proteasome …

The success of Mycobacterium tuberculosis (Mtb) as a human pathogen relies on its ability
to resist eradication by the immune system. The identification of mechanisms that enable …