Nanobiotechnology-enabled tissue engineering strategies have emerged as an innovative
and promising technique in the field of regenerative medical science. The design and …

Biomaterials for tissue scaffolds are key components in modern tissue engineering and
regenerative medicine. Targeted reconstructive therapies require a proper choice of …

In order to expand the promise of regenerative medicine using allogeneic induced
pluripotent stem cells (iPSCs), precise and efficient genome editing of human leukocyte …

Nearly every human malady, be it injury, infection, chronic disease, or degenerative disease,
damages tissues. Moreover, 45% of all deaths can be traced to inflammation-and fibrosis …

Mechanobiologic signals regulate cellular responses under physiologic and pathologic
conditions. Using synthetic biology and tissue engineering, we developed a mechanically …

Osteoarthritis (OA) is one of the most common degenerative joint diseases worldwide,
causing pain, disability, and decreased quality of life. The balance between regeneration …

Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the quality of
life of affected individuals. The underlying mechanisms of OA are diverse and are becoming …

'Mechanogenetics,'a new field at the convergence of mechanobiology and synthetic biology,
presents an innovative strategy to treat, repair, or restore diseased cells and tissues by …

The circadian clock regulates tissue homeostasis through temporal control of tissue-specific
clock-controlled genes. In articular cartilage, disruptions in the circadian clock are linked to a …

Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately
leading to disability and decrease of quality of life. Two key mechanisms have been …