Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …

Glycosylated α-dystroglycan (α-DG) serves as cellular entry receptor for multiple pathogens,
and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least …

THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian
THO in these processes is uncertain, which suggests a differential implication of mRNP …

We report a function of human mRNA decapping factors in control of transcription by RNA
polymerase II. Decapping proteins Edc3, Dcp1a, and Dcp2 and the termination factor TTF2 …

Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …

Amyotrophic lateral sclerosis type 4 (ALS4) is a rare, early-onset, autosomal dominant form
of ALS, characterized by slow disease progression and sparing of respiratory musculature …

Cordycepin (3′ deoxyadenosine) has long been used in the study of in vitro assembled
polyadenylation complexes, because it terminates the poly (A) tail and arrests the cleavage …

R-loops are inherent byproducts of transcription consisting of an RNA: DNA hybrid and a
displaced single-stranded DNA. These structures are of key importance in controlling …