Obesity and cardiovascular disease: revisiting an old relationship

C Koliaki, S Liatis, A Kokkinos - Metabolism, 2019 - Elsevier
A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of
cardiovascular diseases (CVD) including coronary heart disease, heart failure …

Relevance of leptin and other adipokines in obesity-associated cardiovascular risk

MF Landecho, C Tuero, V Valentí, I Bilbao… - Nutrients, 2019 - mdpi.com
Obesity, which is a worldwide epidemic, confers increased risk for multiple serious
conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular …

Resveratrol and vascular function

H Li, N Xia, S Hasselwander, A Daiber - International journal of molecular …, 2019 - mdpi.com
Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating
the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and …

Obesity and COVID-19: molecular mechanisms linking both pandemics

A Ritter, NN Kreis, F Louwen, J Yuan - International journal of molecular …, 2020 - mdpi.com
The coronavirus disease 2019 COVID-19 pandemic is rapidly spreading worldwide and is
becoming a major public health crisis. Increasing evidence demonstrates a strong …

New therapeutic implications of endothelial nitric oxide synthase (eNOS) function/dysfunction in cardiovascular disease

A Daiber, N Xia, S Steven, M Oelze, A Hanf… - International journal of …, 2019 - mdpi.com
The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Circadian rhythm, clock genes, and hypertension: recent advances in hypertension

HM Costello, ML Gumz - Hypertension, 2021 - Am Heart Assoc
Accumulating evidence suggests that the molecular circadian clock is crucial in blood
pressure (BP) control. Circadian rhythms are controlled by the central clock, which resides in …

The role of obesity-induced perivascular adipose tissue (PVAT) dysfunction in vascular homeostasis

A Stanek, K Brożyna-Tkaczyk, W Myśliński - Nutrients, 2021 - mdpi.com
Perivascular adipose tissue (PVAT) is an additional special type of adipose tissue
surrounding blood vessels. Under physiological conditions, PVAT plays a significant role in …

Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice

P Lang, S Hasselwander, H Li, N Xia - Scientific Reports, 2019 - nature.com
The aim of the present study was to compare different diets used to induce obesity in a head-
to-head manner with a focus on insulin resistance and vascular dysfunction. Male C57BL/6J …

Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease

VB Patel, S Shah, S Verma, GY Oudit - Heart failure reviews, 2017 - Springer
Obesity and diabetes are strongly associated with metabolic and cardiovascular disorders
including dyslipidemia, coronary artery disease, hypertension, and heart failure. Adipose …