Mast cells have crucial roles in allergic and other inflammatory diseases. Preclinical
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Mast cells (MCs) are portions of the innate and adaptive immune system derived from bone
marrow (BM) progenitors that are rich in cytoplasmic granules. MC maturation, phenotype …

This review presents evidence that the skin mast cell, in particular the MCTC subtype, is the
primary effector cell in urticaria. Mast cells are located in the upper dermis, the ideal situation …

abstract The signs and symptoms of chronic urticaria (CU) are caused by the activation and
degranulation of skin mast cells (MCs). Recent studies have added to our understanding of …

Abstract Purpose of Review The basophil activation test (BAT) using flow cytometry has
supplanted traditional methods of measuring basophil degranulation using histamine and …

Mast cell activation is common and possibly necessary for maintenance of survival.
Disordered mast cell activation occurs when mast cells are pathologically overproduced or if …

IgE-mediated food allergies are caused by adverse immunologic responses to food proteins.
Allergic reactions may present locally in different tissues such as skin, gastrointestinal and …

Background Food allergy is an increasing public health issue and the most common cause
of life-threatening anaphylactic reactions. Conventional allergy tests assess for the presence …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …