Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular
mechanisms involved in the regulation of conventional outflow resistance and thus …

Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …

Glaucoma is a progressive and chronic neurodegenerative disorder characterized by
damage to the inner layers of the retina and deformation of the optic nerve head. The …

Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary
open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain …

Purpose: Treatment with corticosteroids can result in ocular hypertension and may lead to
the development of steroid-induced glaucoma. The extent to which biomechanical changes …

Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …

Aging is associated with decreased bone mass and accumulation of bone marrow
adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived …

Abstract Background and Objective: Intraocular pressure (IOP) is maintained via a dynamic
balance between the production of aqueous humor and its drainage through the trabecular …

Ageing is the result of changes in biochemical and biophysical processes at the cellular
level that lead to progressive organ decline. Here we focus on the biophysical changes that …