Antiviral strategies targeting host factors and mechanisms obliging+ ssRNA viral pathogens
The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …
emergence of challenging variants has created an urgent need of alternative therapeutic …
Picornavirus morphogenesis
P Jiang, Y Liu, HC Ma, AV Paul… - … and Molecular Biology …, 2014 - Am Soc Microbiol
The Picornaviridae represent a large family of small plus-strand RNA viruses that cause a
bewildering array of important human and animal diseases. Morphogenesis is the least …
bewildering array of important human and animal diseases. Morphogenesis is the least …
Coronavirus infection and cholesterol metabolism
J Dai, H Wang, Y Liao, L Tan, Y Sun, C Song… - Frontiers in …, 2022 - frontiersin.org
Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …
Immunoinformatics and structural vaccinology driven prediction of multi-epitope vaccine against Mayaro virus and validation through in-silico expression
The Mayaro virus (MAYV) belongs to genus “Alphavirus” and family “Togaviridae”. MAYV
has distribution in the Amazonia, Central and Northeastern regions of Brazil. The …
has distribution in the Amazonia, Central and Northeastern regions of Brazil. The …
Requirement of cholesterol in the viral envelope for dengue virus infection
AC Carro, EB Damonte - Virus research, 2013 - Elsevier
The role of cholesterol in the virus envelope or in the cellular membranes for dengue virus
(DENV) infection was examined by depletion with methyl-beta-cyclodextrin (MCD) or …
(DENV) infection was examined by depletion with methyl-beta-cyclodextrin (MCD) or …
Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges
Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal
health, yet effective control measures have proven difficult to implement, and novel means of …
health, yet effective control measures have proven difficult to implement, and novel means of …
Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope
The global situation of diseases transmitted by arthropod-borne viruses such as Dengue
(DENV), Yellow Fever (YFV), Chikungunya (CHIKV) and Zika (ZIKV) viruses is alarming and …
(DENV), Yellow Fever (YFV), Chikungunya (CHIKV) and Zika (ZIKV) viruses is alarming and …
Structure of infective Getah virus at 2.8 Å resolution determined by cryo-electron microscopy
A Wang, F Zhou, C Liu, D Gao, R Qi, Y Yin, S Liu… - Cell Discovery, 2022 - nature.com
Getah virus (GETV), a member of the genus alphavirus, is a mosquito-borne pathogen that
can cause pyrexia and reproductive losses in animals. Although antibodies to GETV have …
can cause pyrexia and reproductive losses in animals. Although antibodies to GETV have …
Porous surfaces: Stability and recovery of coronaviruses
The role of indirect contact in the transmission of SARS-CoV-2 is not clear. SARS-CoV-2
persists on dry surfaces for hours to days; published studies have largely focused on hard …
persists on dry surfaces for hours to days; published studies have largely focused on hard …
Current understanding of the role of cholesterol in the life cycle of alphaviruses
IP Sousa Jr, CAM Carvalho, AMO Gomes - Viruses, 2020 - mdpi.com
Enveloped viruses rely on different lipid classes present in cell membranes to accomplish
several steps of their life cycle in the host. Particularly for alphaviruses, a medically important …
several steps of their life cycle in the host. Particularly for alphaviruses, a medically important …