G-quadruplexes at telomeres: friend or foe?

TM Bryan - Molecules, 2020 - mdpi.com
Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus

NF Lue, C Autexier - Nature structural & molecular biology, 2023 - nature.com
Telomerase is a special reverse transcriptase ribonucleoprotein dedicated to the synthesis
of telomere repeats that protect chromosome ends. Among reverse transcriptases …

A hybrid de novo genome assembly of the honeybee, Apis mellifera, with chromosome-length scaffolds

A Wallberg, I Bunikis, OV Pettersson, MB Mosbech… - BMC genomics, 2019 - Springer
Background The ability to generate long sequencing reads and access long-range linkage
information is revolutionizing the quality and completeness of genome assemblies. Here we …

The i-motif as a molecular target: more than a complementary DNA secondary structure

SL Brown, S Kendrick - Pharmaceuticals, 2021 - mdpi.com
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …

The telomere/telomerase system in chronic inflammatory diseases. Cause or effect?

V Kordinas, A Ioannidis, S Chatzipanagiotou - Genes, 2016 - mdpi.com
Telomeres are specialized nucleoprotein structures located at the end of linear
chromosomes and telomerase is the enzyme responsible for telomere elongation …

Diversity and evolution of telomeric motifs and telomere DNA organization in insects

VA Lukhtanov, EA Pazhenkova - Biological Journal of the …, 2023 - academic.oup.com
The telomerase mechanism and telomeric motifs are vital for maintaining chromosome
integrity. Their functions are conserved in eukaryotic organisms; therefore, it is not surprising …

Telomere organization and the interstitial telomeric sites involvement in insects and vertebrates chromosome evolution

MR Vicari, DP Bruschi, DC Cabral-de-Mello… - … and Molecular Biology, 2022 - SciELO Brasil
Telomere has a central role in chromosomal stability events. Chromosome ends organized
in telomere-loop prevent activation of DNA damage response (DDR) mechanisms, thus …

RNA biology of disease-associated microsatellite repeat expansions

KJ Rohilla, KT Gagnon - Acta neuropathologica communications, 2017 - Springer
Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome
and have important roles in genome evolution and function. However, the expansion of …

Long-read sequencing reveals intra-species tolerance of substantial structural variations and new subtelomere formation in C. elegans

C Kim, J Kim, S Kim, DE Cook, KS Evans… - Genome …, 2019 - genome.cshlp.org
Long-read sequencing technologies have contributed greatly to comparative genomics
among species and can also be applied to study genomics within a species. In this study, to …

What are the functional roles of Piwi proteins and piRNAs in insects?

D Santos, M Feng, A Kolliopoulou, CNT Taning, J Sun… - Insects, 2023 - mdpi.com
Simple Summary Three small RNA pathways, representing miRNAs, siRNAs and piRNAs,
exist in insects. Of the three pathways, piRNAs and Piwi proteins appear to have the most …