In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Simple Summary Early-onset colorectal cancer is increasing in incidence in the United
States, and it is expected to more than double in the next 10 years. There are many risk …

The recognition of dominantly inherited micro-satellite instable (MSI) cancers caused by
pathogenic variants in one of the four mismatch repair (MMR) genes MSH2, MLH1, MSH6 …

Background The early-onset rectal cancer with rapidly increasing incidence is considered to
have distinct clinicopathological and molecular profiles with high-risk features. This leads to …

Colorectal cancer (CRC) epidemiology is changing due to a birth cohort effect, first
recognized by increasing incidence of early onset CRC (EOCRC, age< 50 years). In this …

Early-onset colorectal cancer (EOCRC) has been rising in global prevalence and incidence
over the past several decades. Environmental influences, including generational lifestyle …

Background: Early-onset colorectal cancer (CRC), defined as diagnosis before age 50, has
increased in recent decades. Although more often diagnosed at advanced stage …

Background: The incidence of early-onset colorectal cancer (EOCRC) is rapidly increasing.
Pathogenic germline variants (PGVs) are detected in 16% to 20% of patients who have …

Simple Summary In recent decades, there has been an increase in gastrointestinal
malignancies diagnosed in individuals below the age of 50. Improved recognition of risk …

Cancers in young adults (commonly described as early-onset [EO] cancer) represent a
group of malignancies that have unique and challenging biology and genetic, treatment …