Developments in harmine pharmacology—Implications for ayahuasca use and drug-dependence treatment

DI Brierley, C Davidson - Progress in neuro-psychopharmacology and …, 2012 - Elsevier
Ayahuasca is a hallucinogenic botanical mixture originating in the Amazon area where it is
used ritually, but is now being taken globally. The 2 main constituents of ayahuasca are N, N …

Imidazoline receptors, novel agents and therapeutic potential

GA Head, DN Mayorov - Cardiovascular & Hematological …, 2006 - ingentaconnect.com
The initial realization that agents containing an imidazoline structure may interact with a
distinct class of receptors, has led to a major class of cardiovascular agents, which now has …

Human monoamine oxidase is inhibited by tobacco smoke: β-carboline alkaloids act as potent and reversible inhibitors

T Herraiz, C Chaparro - Biochemical and biophysical research …, 2005 - Elsevier
Monoamine oxidase (MAO) is a mitochondrial outer-membrane flavoenzyme involved in
brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines …

Human monoamine oxidase enzyme inhibition by coffee and β-carbolines norharman and harman isolated from coffee

T Herraiz, C Chaparro - Life sciences, 2006 - Elsevier
Monoamine oxidase (MAO) is a mitochondrial outer-membrane flavoenzyme involved in
brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines …

Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids

T Herraiz, J Galisteo - Food Chemistry, 2015 - Elsevier
Abstract β-Carbolines are bioactive pyridoindole alkaloids occurring in foods, plants and the
human body. Their activity as hydroxyl radical (radical dot OH) scavengers is reported here …

β-Carboline alkaloids in soy sauce and inhibition of monoamine oxidase (MAO)

T Herraiz - Molecules, 2023 - mdpi.com
Monoamine oxidase (MAO) oxidizes neurotransmitters and xenobiotic amines, including
vasopressor and neurotoxic amines such as the MPTP neurotoxin. Its inhibitors are useful as …

High-affinity binding of β-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA …

A Miralles, S Esteban, A Sastre-Coll, D Moranta… - European journal of …, 2005 - Elsevier
This study was designed to determine the affinity and binding profile of β-carbolines for
imidazoline I2 receptors and catalytic sites of monoamine oxidase (MAO)-A/B in rat brain …

N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids

T Herraiz - Food and Chemical Toxicology, 2016 - Elsevier
Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium
cation (MPP+) are selective dopaminergic neurotoxins producing Parkinsonism. MPTP is …

Analysis of monoamine oxidase enzymatic activity by reversed-phase high performance liquid chromatography and inhibition by β-carboline alkaloids occurring in …

T Herraiz, C Chaparro - Journal of Chromatography A, 2006 - Elsevier
Monoamine oxidase (MAO) is a flavin adenine dinucleotide (FAD)-containing enzyme
located at the outer membranes of mitochondria that catalyzes the oxidative deamination of …

Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats

K Guillem, C Vouillac, MR Azar… - European Journal of …, 2006 - Wiley Online Library
Although nicotine is considered to be responsible for the addictive properties of tobacco,
growing evidence underlines the importance of non‐nicotine components in smoking …