The gut microbiome in Alzheimer's disease: what we know and what remains to be explored

S Chandra, SS Sisodia, RJ Vassar - Molecular neurodegeneration, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders

J Horn, DE Mayer, S Chen, EA Mayer - Translational psychiatry, 2022 - nature.com
There is emerging evidence that diet has a major modulatory influence on brain-gut-
microbiome (BGM) interactions with important implications for brain health, and for several …

[HTML][HTML] Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

C Gubert, G Kong, T Renoir, AJ Hannan - Neurobiology of disease, 2020 - Elsevier
The last decade has witnessed an exponentially growing interest in gut microbiota and the
gut-brain axis in health and disease. Accumulating evidence from preclinical and clinical …

[HTML][HTML] Ketogenic diet in Alzheimer's disease

M Rusek, R Pluta, M Ułamek-Kozioł… - International journal of …, 2019 - mdpi.com
At present, the prevalence of Alzheimer's disease, a devastating neurodegenerative
disorder, is increasing. Although the mechanism of the underlying pathology is not fully …

[HTML][HTML] Role of ketogenic diets in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease)

D Włodarek - Nutrients, 2019 - mdpi.com
The goal of this review was to assess the effectiveness of ketogenic diets on the therapy of
neurodegenerative diseases. The ketogenic diet is a low-carbohydrate and fat-rich diet. Its …

Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders

K Augustin, A Khabbush, S Williams, S Eaton… - The Lancet …, 2018 - thelancet.com
High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-
pharmacological treatment for refractory epilepsy. A key mechanism of this treatment is …

Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for …

BJ Neth, A Mintz, C Whitlow, Y Jung, KS Sai… - Neurobiology of …, 2020 - Elsevier
There is currently no established therapy to treat or prevent Alzheimer's disease. The
ketogenic diet supplies an alternative cerebral metabolic fuel, with potential neuroprotective …

The therapeutic role of ketogenic diet in neurological disorders

D Pietrzak, K Kasperek, P Rękawek… - Nutrients, 2022 - mdpi.com
The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has
gained popularity in recent years in the context of neurological diseases (NDs). The …

[HTML][HTML] Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases

Z Jiang, X Yin, M Wang, T Chen, Y Wang, Z Gao… - Aging and …, 2022 - ncbi.nlm.nih.gov
The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …

Neuroprotection by the ketogenic diet: evidence and controversies

SM Gough, A Casella, KJ Ortega, AS Hackam - Frontiers in Nutrition, 2021 - frontiersin.org
The ketogenic diet (KD) is a high-fat low-carbohydrate diet that has been used for decades
as a non-pharmacologic approach to treat metabolic disorders and refractory pediatric …