Some of the most serious consequences of ageing are its effects on skeletal muscle. The
term 'sarcopenia'describes the slow but progressive loss of muscle mass with advancing …

The importance of β-adrenergic signaling in the heart has been well documented, but it is
only more recently that we have begun to understand the importance of this signaling …

In response to skeletal muscle contraction during exercise, paracrine factors coordinate
tissue remodeling, which underlies this healthy adaptation. Here we describe a pH-sensing …

PURPOSE: Some studies report greater muscle hypertrophy during resistance exercise (RE)
training from supplement-timing (ie, the strategic consumption of protein and carbohydrate …

PURPOSE: Studies that have attributed gains in lean body mass to dietary supplementation
during RE training have not reported these changes alongside adaptations at the cellular …

Among organ systems, skeletal muscle is perhaps the most structurally specialized. The
remarkable subcellular architecture of this tissue allows it to empower movement with …

Osteoporosis and sarcopenia are age-related musculoskeletal pathologies that often
develop in parallel. Osteoporosis is characterized by a reduced bone mass and an …

In mammalian systems, skeletal muscle exists in a dynamic state that monitors and regulates
the physiological investment in muscle size to meet the current level of functional demand …

Pericytes are perivascular cells that envelop and make intimate connections with adjacent
capillary endothelial cells. Recent studies show that they may have a profound impact in …

Muscle wasting and weakness are common in many disease states and conditions including
aging, cancer cachexia, sepsis, denervation, disuse, inactivity, burns, HIV-acquired …