In higher eukaryotes, the regulation of developmental gene expression is determined by
enhancers, which are often located at a large distance from the promoters they regulate …

Abstract Broad‐complex, Tramtrack, and Bric‐à‐brac/poxvirus and zinc finger (BTB/POZ)
family proteins are a diverse family of proteins that are characterized by the presence of a …

Genome organization is driven by forces affecting transcriptional state, but the relationship
between transcription and genome architecture remains unclear. Here, we identified the …

The repressive compartment of the nucleus is comprised primarily of telomeric and
centromeric regions, the silent portion of ribosomal RNA genes, the majority of transposable …

Understanding how the metazoan genome is used during development and cell
differentiation is one of the major challenges in the postgenomic era. Early studies in …

Highlights•CTCF and cohesin are required for genome-wide organization of TADs.•TADs
and compartments are not hierarchical forms of chromatin organization.•Strong molecular …

Chromatin insulators are DNA-protein complexes that can prevent the spread of repressive
chromatin and block communication between enhancers and promoters to regulate gene …

Drosophila CP190 and CP60 are transcription factors that are associated with centrosomes
during mitosis. CP190 is an essential transcription factor and preferentially binds to …

Chromatin insulators are remarkable regulatory elements that can bring distant genomic
sites together and block unscheduled enhancer–promoter communications. Insulators act …

Chromatin insulators are functionally conserved DNA–protein complexes situated
throughout the genome that organize independent transcriptional domains. Previous work …