The immunoproteasome and thymoproteasome: functions, evolution and human disease
The basic principle of adaptive immunity is to strictly discriminate between self and non-self,
and a central challenge to overcome is the enormous variety of pathogens that might be …
and a central challenge to overcome is the enormous variety of pathogens that might be …
The ubiquitin–proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders
Y Kitajima, K Yoshioka, N Suzuki - The Journal of Physiological Sciences, 2020 - Springer
Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …
proteasome system (UPS) is recognised as a major intracellular protein degradation system …
Out of control: the role of the ubiquitin proteasome system in skeletal muscle during inflammation
The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …
The ubiquitin–proteasome system in kidney physiology and disease
C Meyer-Schwesinger - Nature Reviews Nephrology, 2019 - nature.com
Intracellular proteins continuously turn over by degradation and synthesis in all organ
tissues. Owing to its irreversible nature, protein degradation is a highly selective process to …
tissues. Owing to its irreversible nature, protein degradation is a highly selective process to …
Role of proteasomes in inflammation
CC Goetzke, F Ebstein, T Kallinich - Journal of clinical medicine, 2021 - mdpi.com
The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …
CANDLE syndrome as a paradigm of proteasome-related autoinflammation
A Torrelo - Frontiers in immunology, 2017 - frontiersin.org
CANDLE syndrome (C hronic A typical N eutrophilic D ermatosis with L ipodystrophy and E
levated temperature) is a rare, genetic autoinflammatory disease due to abnormal …
levated temperature) is a rare, genetic autoinflammatory disease due to abnormal …
The clinical chameleon of autoinflammatory diseases in children
E Sangiorgi, D Rigante - Cells, 2022 - mdpi.com
The very first line of defense in humans is innate immunity, serving as a critical strongpoint in
the regulation of inflammation. Abnormalities of the innate immunity machinery make up a …
the regulation of inflammation. Abnormalities of the innate immunity machinery make up a …
Mammalian proteasome subtypes: Their diversity in structure and function
B Dahlmann - Archives of biochemistry and biophysics, 2016 - Elsevier
The 20S proteasome is a multicatalytic proteinase catalysing the degradation of the majority
of intracellular proteins. Thereby it is involved in almost all basic cellular processes, which is …
of intracellular proteins. Thereby it is involved in almost all basic cellular processes, which is …
Comparison of RT-qPCR and Nanostring in the measurement of blood interferon response for the diagnosis of type I interferonopathies
R Pescarmona, A Belot, M Villard, L Besson, J Lopez… - Cytokine, 2019 - Elsevier
Type I interferonopathies are characterized by an increase of circulating type I interferon
(IFN) concentration. Type I interferonopathies refer to rare Mendelian genetic disorders such …
(IFN) concentration. Type I interferonopathies refer to rare Mendelian genetic disorders such …
Proteasome function shapes innate and adaptive immune responses
IE Kammerl, S Meiners - American Journal of Physiology …, 2016 - journals.physiology.org
The proteasome system degrades more than 80% of intracellular proteins into small
peptides. Accordingly, the proteasome is involved in many essential cellular functions, such …
peptides. Accordingly, the proteasome is involved in many essential cellular functions, such …