Albumin is the most abundant circulating protein in plasma and has recently emerged as a
versatile protein carrier for drug targeting and for improving the pharmacokinetic profile of …

Tumor growth is essentially the result of an evolving cross-talk between malignant and
surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This …

Disruption of the endothelial barrier by tumour-derived secreted factors is a critical step in
cancer cell extravasation and metastasis. Here, by comparative proteomic analysis of …

The ability to effectively target a tumor to achieve complete regression and cure is the
ultimate goal that drives our need to better understand tumor biology. Recently, SPARC has …

Communication between the cell and its surrounding environment, consisting of
proteinaceous (non-living material) and extracellular matrix (ECM), is important for …

The multistep process of metastasis is a major hallmark of cancer progression involving the
cointeraction and coevolution of the tumor and its microenvironment. In the tumor …

Pancreatic ductal adenocarcinoma (PDAC) stands as the poorest prognostic tumor of the
digestive tract, with a 5-year survival rate of less than 5%. Therapeutic options for …

Background SPARC (secreted protein, acidic and rich in cysteine) is closely related with the
progress, invasion and metastasis of malignant tumor and angiogenesis. Methods Using …

SPARC (a secreted protein acidic and rich in cysteine) has a reputation for being potent anti-
cancer and anti-obesity molecule. It is one of the first known matricellular protein that …

We have recently identified that the role of secreted protein acidic and rich in cysteine
(SPARC) in amelioration of peritoneal ovarian carcinomatosis is mediated, at least in part …