Cancer is the second leading cause of death globally and is projected to overtake infectious
disease as the leading cause of mortality in Africa within the next two decades. Cancer is a …

Abstract With only 1.3− 4.3% in total hepatic CYP content, human CYP2D6 can metabolize
more than 160 drugs. It is a highly polymorphic enzyme and subject to marked inhibition by …

Genetic variations in the human cytochrome P450 family 2 subfamily C member 9 (CYP2C9)
and cytochrome P450 family 2 subfamily D member 6 (CYP2D6) genes may affect drug …

Objectives: Head and neck cancer (HNC) is one of the most common cancers. Most
exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to …

Increasing rates of human papillomavirus (HPV)–driven oropharyngeal cancer (OPC) have
largely offset declines in tobacco-associated head and neck squamous cell carcinoma …

The human cytochrome P450 1A (CYP1A) subfamily genes, CYP1A1 and CYP1A2,
encoding monooxygenases are critically involved in biotransformation of key endogenous …

Background Genetics contribute to head and neck cancer (HNC) susceptibility, as has been
indicated in genome-wide association studies. We aimed to appraise the association …

Objective Head and neck cancers are mostly composed of head and neck squamous cell
carcinoma (HNSCC). The incidence and mortality of HNSCC are higher in countries with …

CYP1A1 enzymes act upon these carcinogens before elimination from the body. The aim of
this study was to investigate whether CYP1A1 T3801C polymorphism modulates the …

In first part of this study, a systematic review was designed to explore the involvement of
CYP1A1 and GSTP1 genes in breast cancerogenesis. Based on systematic review, we …