Monocyte/macrophage lineage cells from fetal erythromyeloid progenitors orchestrate bone remodeling and repair
A third of the population sustains a bone fracture, and the pace of fracture healing slows with
age. The slower pace of repair is responsible for the increased morbidity in older individuals …
age. The slower pace of repair is responsible for the increased morbidity in older individuals …
Impact of nanoparticle physicochemical properties on protein corona and macrophage polarization
Macrophages, the major component of the mononuclear phagocyte system, uptake and
clear systemically administered nanoparticles (NPs). Therefore, leveraging macrophages as …
clear systemically administered nanoparticles (NPs). Therefore, leveraging macrophages as …
Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: Microtomographic, histological and …
CC Biguetti, AH De Oliva, K Healy, RH Mahmoud… - PLoS …, 2019 - journals.plos.org
Treatment with cumulative dosages of zoledronic acid (ZA) in elderly patients is a risk factor
for the development of medication-related osteonecrosis of the jaws (MRONJ), mainly …
for the development of medication-related osteonecrosis of the jaws (MRONJ), mainly …
Bone‐Targeted Nanoparticle Drug Delivery System‐Mediated Macrophage Modulation for Enhanced Fracture Healing
Despite decades of progress, developing minimally invasive bone‐specific drug delivery
systems (DDS) to improve fracture healing remains a significant clinical challenge. To …
systems (DDS) to improve fracture healing remains a significant clinical challenge. To …
In situ gelling hydrogel loaded with berberine liposome for the treatment of biofilm-infected wounds
S Li, Y Wang, S Wang, J Xie, T Fu, S Li - Frontiers in Bioengineering …, 2023 - frontiersin.org
Background: In recent years, the impact of bacterial biofilms on traumatic wounds and the
means to combat them have become a major research topic in the field of medicine. The …
means to combat them have become a major research topic in the field of medicine. The …
Effects of cigarette smoke inhalation on the immune‐inflammatory profile of experimental apical periodontitis in rats
ACR da Silva, AMV Vasques… - International …, 2023 - Wiley Online Library
Objective To evaluate the effects of cigarette smoke inhalation on the immune‐inflammatory
profile of experimental apical periodontitis in rats. Methodology In total, 32 male Wistar rats …
profile of experimental apical periodontitis in rats. Methodology In total, 32 male Wistar rats …
Effects of Titanium Corrosion Products on In Vivo Biological Response: A Basis for the Understanding of Osseointegration Failures Mechanisms
Corrosion resistance is a key feature of titanium biocompatibility. However, Ti surfaces
exposed to critical environments (such as, chronic infection and inflammation) can undergo …
exposed to critical environments (such as, chronic infection and inflammation) can undergo …
HGMB1 and RAGE as essential components of Ti osseointegration process in mice
CC Biguetti, F Cavalla, EV Silveira… - Frontiers in …, 2019 - frontiersin.org
The release of the prototypic DAMP High Mobility Group Box 1 (HMGB1) into extracellular
environment and its binding to the Receptor for Advanced Glycation End Products (RAGE) …
environment and its binding to the Receptor for Advanced Glycation End Products (RAGE) …
New surgical model for bone–muscle injury reveals age and gender-related healing patterns in the 5 lipoxygenase (5LO) knockout mouse
CC Biguetti, MCR Couto, ACR Silva… - Frontiers in …, 2020 - frontiersin.org
Signaling lipid mediators released from 5 lipoxygenase (5LO) pathways influence both bone
and muscle cells, interfering in their proliferation and differentiation capacities. A major …
and muscle cells, interfering in their proliferation and differentiation capacities. A major …
Lack of 5-lipoxygenase in intramembranous and endochondral 129Sv mice skeleton and intramembranous healing
GB Simionato, ACR da Silva, AH de Oliva… - Archives of Oral …, 2021 - Elsevier
Objective To analyze the lack of 5-lipoxygenase (5LO) on dental socket healing and post-
natal phenotype of intramembranous and endochondral bones. Design Wild type (WT) …
natal phenotype of intramembranous and endochondral bones. Design Wild type (WT) …