A third of the population sustains a bone fracture, and the pace of fracture healing slows with
age. The slower pace of repair is responsible for the increased morbidity in older individuals …

Macrophages, the major component of the mononuclear phagocyte system, uptake and
clear systemically administered nanoparticles (NPs). Therefore, leveraging macrophages as …

Treatment with cumulative dosages of zoledronic acid (ZA) in elderly patients is a risk factor
for the development of medication-related osteonecrosis of the jaws (MRONJ), mainly …

Despite decades of progress, developing minimally invasive bone‐specific drug delivery
systems (DDS) to improve fracture healing remains a significant clinical challenge. To …

Background: In recent years, the impact of bacterial biofilms on traumatic wounds and the
means to combat them have become a major research topic in the field of medicine. The …

Objective To evaluate the effects of cigarette smoke inhalation on the immune‐inflammatory
profile of experimental apical periodontitis in rats. Methodology In total, 32 male Wistar rats …

Corrosion resistance is a key feature of titanium biocompatibility. However, Ti surfaces
exposed to critical environments (such as, chronic infection and inflammation) can undergo …

The release of the prototypic DAMP High Mobility Group Box 1 (HMGB1) into extracellular
environment and its binding to the Receptor for Advanced Glycation End Products (RAGE) …

Signaling lipid mediators released from 5 lipoxygenase (5LO) pathways influence both bone
and muscle cells, interfering in their proliferation and differentiation capacities. A major …

Objective To analyze the lack of 5-lipoxygenase (5LO) on dental socket healing and post-
natal phenotype of intramembranous and endochondral bones. Design Wild type (WT) …