Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …

Background Current therapeutic options for Chagas' disease are limited to benznidazole
and nifurtimox, which have been associated with low cure rates in the chronic stage of the …

In this" Critical Review" we made a historical introduction of drugs assayed against Chagas
disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental …

Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma
and Leishmania, which are human pathogens with devastating health and economic effects …

The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Current knowledge of the biochemistry of Trypanosoma cruzi has led to the development of
new drugs and the understanding of their mode of action. Some trypanocidal drugs such as …

Background This report describes a real-time PCR (Q-PCR) strategy to quantify
Trypanosoma cruzi (T. cruzi) DNA in peripheral blood samples from Chagas disease …

Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …

Current treatments for diseases caused by apicomplexan and trypanosomatid parasites are
inadequate due to toxicity, the development of drug resistance and an inability to eliminate …