Wnt signalling is an essential player in tissue formation, notably in the regulation of stem cell
function. Wnt signalling is best known for its roles in G1/S progression. However, a complex …

Abstract β-Catenin is a well-established driver of many cancers; however, there are
challenges in developing agents targeting β-catenin for clinical use. Recent progress has …

Rationale: β-catenin is a component for cell adhesion and a transcriptional coactivator in
epithelial-mesenchymal transition (EMT). Previously we found that catalytically active PLK1 …

Polo-like kinase 1 (Plk1) is considered an attractive target for anticancer therapy. Over the
years, studies on the noncatalytic polo-box domain (PBD) of Plk1 have raised the …

Multicellular systems, such as epithelial cell collectives, undergo transitions similar to those
in inert physical systems like sand piles and foams. To remodel or maintain tissue …

Cytokinesis is the last step of cell division, when one cell physically divides into two cells.
Cytokinesis is driven by an equatorial contractile ring and signals from antiparallel …

Lung adenocarcinoma (LUAD), responsible for nearly half of lung cancer cases, is one of
the most prevalent and lethal malignant tumors globally. There is increasing evidence …

Primary cilium is an important hub for cell signaling and dysregulation of primary cilia
assembly and disassembly is associated with the development of cancer and …

肾纤维化是指肾脏在各种原发或继发因素下导致其功能损伤, 结构改变, 逐渐出现肾小球,
血管及间质纤维基质沉积增加, 最终导致慢性肾脏病(chronic kidney disease, CKD) …

The cell cycle and cell division are processes that need to be highly controlled in order for
organisms to function and to prevent diseases. Cell behavior is controlled through many …