SIRT1 and SIRT2 activity control in neurodegenerative diseases
Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …
Key signaling pathways in aging and potential interventions for healthy aging
Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …
Terpenoids as potential geroprotectors
E Proshkina, S Plyusnin, T Babak, E Lashmanova… - Antioxidants, 2020 - mdpi.com
Terpenes and terpenoids are the largest groups of plant secondary metabolites. However,
unlike polyphenols, they are rarely associated with geroprotective properties. Here we …
unlike polyphenols, they are rarely associated with geroprotective properties. Here we …
SIRT1 activation by Taurine: In vitro evaluation, molecular docking and molecular dynamics simulation studies
AD Kp, ARS Janakirama, A Martin - The Journal of Nutritional Biochemistry, 2022 - Elsevier
Abstract Sirtuin1 (SIRT1) plays a major role in regulating different genes involved in several
metabolic pathways. SIRT1 activators have protective role in several metabolic disorders …
metabolic pathways. SIRT1 activators have protective role in several metabolic disorders …
Anti-aging biomaterial sturgeon chondroitin sulfate upregulating anti-oxidant and SIRT-1/c-fos gene expression to reprogram stem cell senescence and prolong …
AK Singh, BY Peng, ST Chien, CH Chan… - Biomaterials …, 2023 - pubs.rsc.org
Aging involves tissue and cell potential dysfunction characterized by stem cell senescence
and extracellular matrix microenvironment (ECM) alteration. Chondroitin sulfate (CS), found …
and extracellular matrix microenvironment (ECM) alteration. Chondroitin sulfate (CS), found …
Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors
J Naß, T Efferth - Phytomedicine, 2021 - Elsevier
Background Depression and stress-related disorders are leading causes of death
worldwide. Standard treatments elevating serotonin or noradrenaline levels are not …
worldwide. Standard treatments elevating serotonin or noradrenaline levels are not …
Mechanistic evaluation of ursolic acid against rotenone induced Parkinson's disease–emphasizing the role of mitochondrial biogenesis
Parkinson's disease (PD) is an age associated, progressive and a second most common
neurodegenerative disease. It is caused due to degeneration of dopaminergic neurons in …
neurodegenerative disease. It is caused due to degeneration of dopaminergic neurons in …
Natural products and skeletal muscle health
Z Qu, S Zhou, P Li, C Liu, B Yuan, S Zhang… - The Journal of Nutritional …, 2021 - Elsevier
Skeletal muscle (SkM) is essential for body movement, energy metabolism, and material
metabolism, and directly influences the quality of human life. Aging, chronic diseases, and …
metabolism, and directly influences the quality of human life. Aging, chronic diseases, and …
Using Drosophila as a platform for drug discovery from natural products in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder with no
cure. Despite intensive research, most of the currently available therapies are only effective …
cure. Despite intensive research, most of the currently available therapies are only effective …
A patent review on HMGB1 inhibitors for the treatment of liver diseases
R Raj, P Shen, B Yu, J Zhang - Expert Opinion on Therapeutic …, 2024 - Taylor & Francis
Introduction HMGB1 is a non-histone chromatin protein released or secreted in response to
tissue damage or infection. Extracellular HMGB1, as a crucial immunomodulatory factor …
tissue damage or infection. Extracellular HMGB1, as a crucial immunomodulatory factor …