Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Phenotypic variation is traditionally parsed into components that are directed by genetic and
environmental variation. The line between these two components is blurred by inherited …

The histone tails on the nucleosome surface are subject to enzyme-catalyzed modifications
that may, singly or in combination, form a code specifying patterns of gene expression …

Like many eukaryotes, bacteria make widespread use of postreplicative DNA methylation for
the epigenetic control of DNA-protein interactions. Unlike eukaryotes, however, bacteria use …

We present an analysis of over 1,100 of the∼ 10,000 predicted proteins encoded by the
genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of …

Repeat-induced point mutation (RIP) is a homology-based process that mutates repetitive
DNA and frequently leads to epigenetic silencing of the mutated sequences through DNA …

The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …

Chromatin, composed of DNA wrapped around an octamer of histones, is the relevant
substrate for all genetic processes in eukaryotic nuclei. Changes in chromatin structure are …

A-to-I RNA editing catalyzed by adenosine-deaminase-acting-on-RNA (ADARs) was
assumed to be unique to metazoans because fungi and plants lack ADAR homologs …

The filamentous fungus Neurospora crassa has provided a rich source of knowledge on
epigenetic phenomena that would have been difficult or impossible to gain from other …