Normal cells after a defined number of successive divisions or after exposure to genotoxic
stresses are becoming senescent, characterized by a permanent growth arrest. In addition …

Mutational activation of K-Ras is a key genetic event involved in the initiation of pancreatic
carcinogenesis. However, K-Ras generally fails to transform precursor lesions into invasive …

Males, who are bigger and stronger than females, die younger in most species from flies to
mammals including humans. Cellular mass growth is driven in part by mTOR (Target of …

Cellular senescence is associated with global chromatin changes, altered gene expression,
and activation of chronic DNA damage signaling. These events ultimately lead to …

Cellular senescence is a state of growth arrest implicated in both physiological and
pathophysiological conditions. In aging cells, while senescence is induced via replicative …

Ageing is a deterioration of organ function that increases the susceptibility for diseases. This
deterioration is due to an impairment of cellular homeostasis occurred in response to the …

This unique synthesis of chapters from top experts in their fields targets the essential area of
cancer biomarkers and the need for better and more rigorous design and clinical trials. The …