Oxidative stress, a cytopathic outcome of excessive generation of ROS and the repression of
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and
immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is …

Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment
options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera; Biogen …

Arterial hypertension (HTN) is one of the most prevalent entities globally, characterized by
increased incidence and heterogeneous pathophysiology. Among possible etiologies …

Background and aims The process of endothelial repair in diabetic patients after stent
implantation was significantly delayed compared with that in non-diabetic patients, and …

COVID-19 has rapidly spread worldwide and incidences of hospitalisation from respiratory
distress are significant. While a vaccine is in the pipeline, there is urgency for therapeutic …

Cannabidiol (CBD), a non-psychoactive cannabinoid, has been reported to mediate
antioxidant, anti-inflammatory, and anti-angiogenic effects in endothelial cells. This study …